New research explores modulating lung fibroblast activation through senolysis of senescent alveolar epithelial cells in IPF.
- Research paper titled "Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells" published in Aging.
- Idiopathic pulmonary fibrosis (IPF) is an age-related disease with poor prognosis, targeting alveolar epithelial cell senescence is a potential therapeutic strategy.
- Researchers developed a system using conditioned medium transfer from senescent alveolar epithelial cells onto normal lung fibroblasts to study fibrotic phenotype.
- Senescent alveolar epithelial cells exhibited hallmarks of cellular senescence and an expression profile resembling IPF lung cells.
- Fibroblast activation was attenuated by senolytics but not by standard-of-care agents, providing a new model for studying IPF drug development.
Source link
Pulmonary Medicine, Pathology & Lab Medicine