Key mechanisms of skeletal muscle regeneration and growth following recent research at the University of Houston College of Pharmacy.
- Loss of IRE1α in satellite cells inhibits the formation of regenerating myofibers, potentially leading to muscle disorders.
- Research from the University of Houston College of Pharmacy uncovers key mechanisms of skeletal muscle regeneration post-exercise.
- Muscle stem cells, named satellite cells, play a crucial role in the regenerative capacity of adult skeletal muscles.
- The increase in levels of IRE1 or XBP1 in muscle stem cells can improve muscle repair and reduce disease severity.
- The IRE1α/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle, leading to significant growth in muscle size.
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Orthopaedics, Rehabilitation Medicine, Physical Therapy