Novel stealth cancer therapy developed by Yale researchers uses Trojan-horse approach to target tumors effectively.
- Yale Cancer Center researchers have developed a novel Trojan-horse therapy that disguises tumor-fighting antibodies within molecules cancer uses to nourish tumor growth.
- This therapy has been effective against various cancer tumor types in the laboratory, including brain tumors that are difficult to reach due to the blood-brain barrier.
- The antibodies in this therapy are strategically redesigned from lupus to target tumors while minimizing lupus effects, and are able to track down tumors using nucleic acid molecules grabbed by cancer to grow.
- Unlike traditional therapies that target specific surface markers, this new therapy targets extracellular nucleic acids found in tumors, making it effective against a wide range of tumors regardless of type.
- The therapy shows promise for other diseases beyond cancer, such as heart attacks, strokes, or traumatic injuries, by delivering drugs, proteins, or gene therapies to damaged areas associated with increased DNA release.
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