Researchers at Drexel University have discovered new drugs targeting breast cancer brain metastases, offering promising results.
- Researchers at Drexel’s College of Medicine have identified new drugs that are effective in shrinking breast cancer tumors that have spread to the brain.
- By targeting a key metabolic enzyme in cancer cells in the brain, the researchers were able to shrink tumors in a mouse model for the first time.
- These drugs work by inhibiting the enzyme ACSS2, a key player in brain tumor growth, and were found to cross the blood-brain barrier successfully.
- The compounds AD-5584 and AD-8007 showed promise in killing cancer cells, blocking tumor growth, and reducing key energy sources for cancer cells.
- The research team is working on further optimizing these compounds for clinical trials in patients with the hope of developing more effective therapies for breast cancer brain metastases.
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Oncology,Nursing,Neurology