Exploring the pivotal role of Non-coding RNAs in breast cancer development through the Notch signaling pathway.
- Non-coding RNAs (NcRNAs) such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) play a crucial role in regulating gene expression and cellular functions in breast cancer.
- The Notch signaling pathway is involved in various cellular processes and has been linked to the development and progression of breast cancer, especially in aggressive subtypes like triple-negative breast cancer (TNBC).
- NcRNAs interact with the Notch pathway by directly targeting components of the pathway or by regulating its activity through various mechanisms, influencing cancer cell proliferation, invasion, and metastasis.
- Therapeutically targeting NcRNAs or their interactions with the Notch pathway components could lead to innovative treatments that may significantly impact patient care and prognosis.
- Understanding the interactions between NcRNAs and the Notch signaling pathway offers promising avenues for breast cancer diagnosis, prognosis, and the development of novel therapeutic strategies that could enhance treatment efficacy and patient outcomes.
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Oncology, Pathology&LabMedicine