Exploring the genetic diversity of rabies virus in Kenya using whole-genome sequencing.
- Rabies, a viral disease causing encephalitis, has a long history dating back to Egypt around 2300 BCE.
- The rabies virus is primarily transmitted through the bite of an infected animal, leading to aggressive behavior and a high fatality rate once clinical signs appear.
- Different lyssaviruses exist, with rabies virus causing the majority of human deaths globally, mainly through dog-mediated transmissions.
- Kenya has a history of rabies with domestic dogs being the main source, and efforts are being made to control the disease through mass dog vaccinations and post-exposure prophylaxis.
- Whole-genome sequencing of wild RABV strains from Kenya revealed localized viral lineages, limited viral migration between regions, and overall similarity to current vaccine strains, emphasizing the need for ongoing monitoring and surveillance in the country.
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Infectious Diseases, Public Health & Prevention, Veterinary Medicine