Histoplasmosis is an endemic fungal infection with high mortality rates among immunocompromised individuals, prompting a need for improved diagnostics and treatments.
- Histoplasmosis is an endemic fungal infection that can be fatal in immunocompromised persons, such as those with HIV, but is often underdiagnosed worldwide.
- Enzyme immunoassays have been developed to detect Histoplasma antigen in urine samples, aiding in the diagnosis of histoplasmosis, especially in resource-limited settings.
- A systematic review found that 11% of persons with HIV tested positive for Histoplasma antigen in their urine, with higher prevalence among those with advanced HIV disease and symptomatic individuals.
- The review highlighted the need for systematic screening programs for histoplasmosis among certain populations to improve clinical outcomes.
- Further research is required to understand the clinical significance of asymptomatic Histoplasma antigenuria among persons with HIV and develop rapid diagnostic assays for improved management of the disease.
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Infectious Diseases, HIV/AIDS, Epidemiology, Public Health & Prevention