Explore the cytotoxic impacts of cyclophosphamide on male reproductive health in a comprehensive review published by Xia & He Publishing Inc.
- Cyclophosphamide (CP) is a widely used chemotherapeutic and immunosuppressive agent that has significant impacts on reproductive health in both males and females.
- CP induces reproductive toxicity by affecting genetic stability, hormonal balance, and gonadal function.
- CP’s cytotoxic properties lead to genetic instability in males, resulting in disrupted spermatogenesis and potential transmission of genetic abnormalities to offspring.
- In females, CP suppresses ovarian endocrine activity, leading to reproductive complications such as amenorrhea, precocious puberty, and decreased ovarian reserve.
- Understanding the mechanisms of CP-induced reproductive toxicity is crucial for developing protective strategies such as sperm banking and pharmacological interventions to mitigate its long-term adverse effects.
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Endocrinology,Dermatology,Urology