- The study investigates the effects of polyethylene terephthalate (PET) microplastics on the neuronal population in the porcine jejunum, focusing on similarities between human and pig digestive systems.
- The enteric nervous system (ENS) plays a crucial role in regulating immune responses, enzyme secretion, and nutrient absorption in the jejunum through nerve plexuses.
- Exposure to microplastics is a growing concern for both humans and animals, with significant implications for environmental and health impacts.
- The study found that oral exposure to microplastics caused changes in neurotransmitter levels, mitochondrial dysfunction, oxidative stress, gut microbiome disruption, and inflammation in the porcine jejunum.
- While more research is needed to fully understand these mechanisms, the study suggests that certain neurotransmitters may induce inflammation in the ENS of the porcine jejunum.
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Gastroenterology, Neurology