- Amyloid-beta (A-beta) aggregates, associated with neurodegenerative diseases like Alzheimer’s, have been a mystery in terms of how they come together and break apart.
- Researchers at Washington University in St. Louis developed a new imaging technique called single-molecule orientation–localization microscopy (SMOLM) to study A-beta structures at the nano scale.
- The study revealed that A-beta can grow and decay in various ways, with some structures maintaining stability, while others undergo changes in beta-sheet orientations.
- By tracking the underlying organization of A-beta, researchers found different subtypes of remodeling that were previously unseen with traditional imaging methods.
- This groundbreaking research opens up new possibilities to understand amyloid architecture and may eventually lead to the development of novel treatments for neurodegenerative diseases.
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Pathology & Lab Medicine, Neurology