Summary
- A recent study included people with Type 2 diabetes with a median age of 67 years, where 36.9% were females and 19.5% had advanced fibrosis.
- Cardiovascular disease and metabolic risk factors were more common in individuals with advanced fibrosis.
- People with advanced fibrosis had lower health-related quality of life (HRQL), with higher levels of problems in mobility, usual activities, and pain/discomfort dimensions.
- obesity and advanced fibrosis were identified as independent predictors of poor HRQL in individuals with Type 2 diabetes, according to the multivariable linear regression analysis.
- Overall, the study highlights the impact of advanced fibrosis and obesity on HRQL in people with Type 2 diabetes, emphasizing the importance of managing these factors to improve quality of life.
A recent study on people with Type 2 Diabetes Mellitus (T2DM) has revealed some interesting findings about their health-related quality of life (HRQL) and clinical characteristics. The study, which included a cohort with a median age of 67 years and 36.9% females, found that 19.5% of participants had advanced fibrosis (AF) and 77.9% had significant liver disease (SLD), with most of them having mild to moderate SLD.
Cardiovascular disease (CVD) was more common in individuals with AF, and metabolic risk factors were more prevalent in this subgroup. Higher levels of gamma-glutamyl transferase (GGT) were also found in those with AF, as well as a higher use of insulin for T2DM treatment.
The study also looked at HRQL in people with T2DM using the EQ-5D-3L questionnaire. The results showed that participants reported the highest levels of pain/discomfort and mobility, while self-care was the least problematic dimension. However, a significant number of individuals reported moderate to extreme problems in the pain/discomfort dimension.
Comparing HRQL between individuals with AF and those without AF, the study found that participants with AF had lower overall HRQL scores, with higher levels of impairment in mobility, usual activities, and pain/discomfort dimensions. Although the anxiety/depression dimension had higher scores in individuals with AF, there was no significant difference compared to those without AF.
The study also identified clinical predictors of impaired HRQL in people with T2DM. obesity and AF were found to be independent predictors of poor HRQL in both univariable and multivariable regression analyses. Age, obesity, and AF remained as the only independent predictors of poor HRQL in participants based on the TTO index value and the VAS.
Overall, the study provides important insights into the health status and quality of life of people with T2DM, highlighting the significant impact of advanced fibrosis and obesity on HRQL. These findings underscore the importance of targeted interventions and support for individuals with T2DM to improve their health outcomes and overall well-being.
In conclusion, understanding the clinical characteristics and HRQL of people with T2DM is vital for providing comprehensive care and support for this population. By identifying key predictors of poor HRQL, healthcare providers can intervene early and effectively to enhance the quality of life for individuals living with T2DM. This study contributes valuable information to the field of diabetes management and encourages further research to explore interventions that can improve HRQL in this population.
Diabetes & Endocrinology,Gastroenterology,Internal Medicine