- A new preclinical model for studying Parkinson’s disease has been developed by Weill Cornell Medicine researchers, offering a unique platform for research.
- By knocking out a key component involved in protein transportation in rod cells of mice, researchers were able to induce the accumulation of alpha-synuclein aggregates associated with Parkinson’s disease.
- This model closely mimics the human disease and could potentially lead to an easier method for detecting Parkinson’s in people.
- The study’s findings suggest that knocking out the protein VPS35 in rod cells could be a promising strategy for studying disease mechanisms and testing therapies.
- The researchers also identified potential signs of Parkinson’s disease using a standard ophthalmological device, paving the way for future clinical trials.
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Neurology, Parkinson’s disease, Preclinical model