-
A new study by scientists at deCODE Genetics, a subsidiary of Amgen, reveals that sequence variants play a significant role in the relationship between DNA methylation and gene expression, with these variants also being linked to various diseases and human traits.
-
The research, published in the scientific journal Nature Genetics, focuses on the correlation between CpG methylation and gene expression being driven by sequence variants.
-
Nanopore sequencing technology developed by ONT allows for real-time analysis of DNA sequences by pulling DNA molecules through protein pores and measuring electric current to identify passing nucleotides and detect chemical modifications like DNA methylation.
-
By utilizing Nanopore sequencing, scientists can directly measure DNA methylation and achieve longer DNA sequence reads than previous technologies, enabling the measurement of DNA methylation on both parental chromosomes to investigate correlations between sequence variants, DNA methylation, and gene expression.
- The study demonstrates that many noncoding sequence variants linked to diseases correspond to variants associated with DNA methylation, providing insights into how these variants contribute to disease progression and offering a clearer understanding of the impact of sequence variants on human health.
Source link
Genetics, Disease Risk, Allergy & Clinical Immunology, Cardiology, Dermatology, Diabetes & Endocrinology, Infectious Diseases