Summary
- Four GEO datasets were analyzed to identify gene signatures in PCOS and sedentary individuals.
- The analysis revealed common gene sets related to aromatic compound metabolism in both PCOS and sedentary individuals.
- The study also identified common miRNAs shared by PCOS and sedentary individuals.
- Pathway-related patterns mediated by pathway-related genes were linked to survival in endometrial cancer.
- NAA15 was found to promote EC cell proliferation and migration, highlighting its potential role in endometrial cancer progression.
Researchers have discovered a link between Polycystic Ovary Syndrome (PCOS) and a sedentary lifestyle through a study using data from different gene expression datasets. The study identified specific genes and pathways that are associated with both PCOS and being sedentary. These findings provide valuable insights into the potential underlying mechanisms of these conditions.
Through their analysis, the researchers found that certain genes related to the cellular aromatic compound metabolic process were significantly connected to both PCOS and a sedentary lifestyle. This suggests that this particular biological process plays a crucial role in the development of these conditions. The study also identified common microRNAs (miRNAs) that are shared between individuals with PCOS and those who are sedentary. These miRNAs were found to be involved in various biological processes, including the cellular aromatic compound metabolic process.
In addition to identifying common genes and pathways, the researchers also examined the tumor microenvironment in individuals with a high expression of the aromatic compound metabolic process (ACMP) pathway. They found differences in immune cell infiltration and immune checkpoint expression between those with high and low expression of the ACMP pathway. This indicates that the immune system may play a role in the development and progression of conditions related to the ACMP pathway.
One particular gene, NAA15, was found to be significantly differentially expressed in individuals with high and low expression of the ACMP pathway. High expression of NAA15 was associated with shorter survival time in individuals with endometrial cancer. Further experiments showed that NAA15 promoted the proliferation and migration of endometrial cancer cells, indicating its potential role in the progression of this type of cancer.
Overall, this study sheds light on the intricate relationship between gene expression, biological processes, and disease development in individuals with PCOS and a sedentary lifestyle. The findings provide valuable insights for further research into the underlying mechanisms of these conditions and potential treatment options.
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Ob/Gyn & Women’s Health, Oncology, Diabetes & Endocrinology