Summary
- Mice were divided into different groups and subjected to various interventions to evaluate swallowing quality.
- A mouse tongue muscle tension detection device was designed and manufactured to assess swallowing frequency, swallowing time, and tongue muscle tension.
- Techniques such as immunohistochemistry, immunofluorescence staining, and western blotting were used to detect the expression levels of specific proteins in the brain tissues.
- qRT-PCR was performed to analyze the gene expression levels of LncRNA-ZFAS1, miR-590, MIB1, TXNIP, and Trx1.
- Co-immunoprecipitation assay was used to detect protein-protein interactions in the samples collected from the mice.
Researchers conducted a study using male mice to investigate a potential treatment for Parkinson’s disease. The mice were divided into different groups, including a control group that received no treatment, a group that received a drug called MPTP to induce Parkinson’s disease symptoms, a group that received a type of brain stimulation called rTMS, a group that received a placebo stimulation, and a group that received a drug called L-Dopa.
The researchers used a device to measure the swallowing abilities of the mice before and after treatment. They also analyzed brain tissues to study the effects of the treatments on specific cells and proteins related to Parkinson’s disease. The results showed that the rTMS treatment had a positive impact on the mice’s swallowing abilities and reduced the levels of certain proteins associated with the disease.
Overall, the study suggests that rTMS could be a promising treatment for Parkinson’s disease. Further research is needed to confirm these findings and explore the potential benefits of this therapy in humans.
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Neurology, Gastroenterology, Immunology