Summary
- Study was approved by the Research Ethics Committee and informed consent was waived due to retrospective nature
- Patients included those with specific criteria who underwent focal therapy (FT) with high-intensity focused ultrasound (HIFU) or robot-assisted radical prostatectomy (RARP)
- Procedures for RARP and FT with HIFU were described, along with post-treatment monitoring of PSA levels and urinary function
- Oncological outcomes were measured in terms of freedom from failure, while quality of life was assessed using the Expanded Prostate Cancer Index Composite (EPIC)
- Statistical analysis included propensity score matching, FFS and QOL assessment, and win ratio calculation comparing outcomes between FT and RARP groups
A study on ethical matters and treatments for prostate cancer was conducted with approval from the Research Ethics Committee of the University of Tokyo. Patients meeting specific criteria underwent focal therapy (FT) with high-intensity focused ultrasound (HIFU) or robot-assisted radical prostatectomy (RARP). Oncological outcomes were measured using the Freedom from Specific Failure (FFS) metric, while quality of life (QOL) was assessed using the Expanded Prostate Cancer Index Composite (EPIC).
The study analyzed data from patients treated between 2016 and 2020, who met certain criteria and underwent either FT with HIFU or RARP. The surgical procedure for RARP was transperitoneal, with emphasis on post-operative care to improve urinary continence. HIFU treatment used ultrasonic energy to target prostate cancer lesions, with follow-up assessments on PSA levels and QOL through the EPIC every 3 months post-treatment.
Statistical analyses including propensity score matching and win ratio analysis were conducted to compare outcomes between the FT and RARP groups. FFS rates, QOL using EPIC scores, and urinary function domain assessments were used to evaluate treatment success. The findings of the study provide valuable insights for healthcare professionals in treating prostate cancer patients using different focal therapy approaches.
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Urology, Oncology, General Surgery