Summary
- Coronary atherosclerosis is common even in asymptomatic adults without traditional risk factors.
- Higher levels of atherogenic lipoproteins, such as LDL-C, non-HDL-C, and apoB, are associated with an increased prevalence of coronary atherosclerosis.
- Men have higher body mass index and atherogenic lipoprotein levels compared to women.
- Even in low-risk adults, coronary plaque becomes more prevalent with age and higher levels of atherogenic lipoproteins.
- Healthcare professionals should consider lowering serum lipoproteins through diet, lifestyle changes, or medication to prevent or delay coronary atherosclerosis.
A recent study published in the journal JACC Advances revealed that coronary atherosclerosis, a major cause of cardiovascular disease, is common even among seemingly healthy middle-aged adults with no traditional risk factors. The researchers found that individuals with higher levels of atherogenic lipoproteins, such as LDL-C, non-HDL-C, and apoB, were more likely to have coronary plaque, indicating the presence of atherosclerosis. Despite having low-risk profiles, a significant portion of the study participants showed signs of coronary atherosclerosis, highlighting the importance of monitoring and managing cholesterol levels to prevent cardiovascular issues.
The study, conducted on a large group of asymptomatic adults, showed that higher levels of LDL-C, non-HDL-C, and apoB were associated with an increased risk of coronary plaque development, even in individuals considered low-risk based on traditional factors like hypertension, diabetes, or tobacco use. While the participants in the study had relatively low predicted risks of cardiovascular disease, the presence of coronary plaque suggests that a focus on lowering atherogenic lipoproteins through lifestyle changes, diet, or medication could help reduce the progression of atherosclerosis and improve overall health outcomes. These findings underscore the importance of lipid-lowering strategies for maintaining heart health, regardless of apparent risk factors, in individuals who may appear healthy but could still benefit from cholesterol management.
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Cardiology, Internal Medicine, Public Health & Prevention.