Genetic factors play a significant role in the severity of COVID-19, with research highlighting the impact of TLR7 and other genes on disease progression.
- Researchers from the University Hospital Bonn investigated a large group of individuals to understand genetic factors that contribute to severe cases of COVID-19.
- They confirmed the role of the TLR7 gene in severe COVID-19 cases in men and found evidence of its contribution in women as well.
- Genetic changes in three other genes of the innate immune system were also found to play a role in severe COVID-19 cases.
- Mutations in the TLR7 gene were observed more frequently in severely affected COVID-19 patients, along with mutations in the genes TBK1, INFAR1, and IFIH1.
- Gender-specific differences were identified in the progression of COVID-19 due to hereditary factors, particularly in the TLR7 gene located on the X chromosome.
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Genetic Mutations, TLR7, COVID-19, Infectious Diseases, Immunology, Pulmonary Medicine