New study examines the correlation between DNA methylation, gene expression, and sequence variants linked to diseases and human traits.
- A study by scientists at deCODE Genetics shows that sequence variants drive the correlation between DNA methylation and gene expression, linked to various diseases and human traits.
- Nanopore sequencing by ONT allows real-time analysis of DNA sequences, detecting DNA methylation and providing longer reads of DNA sequences.
- The study demonstrates that sequence variants impact DNA methylation, contributing to diseases and human traits, particularly in the noncoding genome.
- By studying the effects on DNA methylation, researchers were able to understand how noncoding sequence variants lead to diseases, providing new insights into disease progression.
- The correlation between DNA methylation and gene expression can be attributed to sequence variants, indicating these variants as the driving factor in regulating gene expression.
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Genetics, DNA methylation, Diseases, Immunology, Oncology, Pathology & Lab Medicine