Study reveals how docosahexaenoic acid (DHA) inhibits gastric contractions by targeting specific calcium channels.
- DHA, found in fish oil, inhibits gastric fundus smooth muscle contractions induced by substances like bradykinin.
- The research group discovered a new action of DHA in inhibiting the Orai1 channel, which is a store-operated Ca2+ channel.
- DHA not only inhibits voltage-dependent Ca2+ channels (VDCCs) but also the Orai1 channel, suggesting its role in controlling excessive gastric motility.
- The study findings were published in Scientific Reports, highlighting the inhibitory effects of DHA on gastric contractions.
- This research provides valuable insights for healthcare professionals on the potential benefits of DHA in regulating gastric motility.
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Gastroenterology, Pharmacists