- The tumor microenvironment (TME) plays a vital role in tumor development, metastasis, and recurrence.
- The complex physical structure of TME hinders drug delivery and contributes to immunotherapy resistance.
- Physical stimulations like ionizing radiation, light, electricity, and ultrasound can modify TME by altering tumor vasculature, extracellular matrix, and activating immune responses.
- These physical stimulations enhance the effectiveness of adjuvant chemotherapy and immunotherapy for cancer treatment.
- The article highlights the importance of breaking the physical barrier limitations of TME to optimize existing tumor treatment protocols.
Source link
Oncology, Radiology, Immunology, Cancer Therapy