- A large-scale genome-wide association study conducted using data from the US Department of Veterans Affairs Million Veterans Program fills crucial gaps in our understanding of the relationships between genes, traits, and diseases across diverse populations.
- The study highlights the importance of diversity in genetic studies and the need for expanding representation in future investigations to improve precision medicine approaches.
- Researchers leveraged data from the MVP, which includes over 635,000 participants from diverse backgrounds, to conduct GWAS and analyze 2068 traits in African, Admixed American, East Asian, and European populations.
- The findings revealed more similarities than differences in gene-trait associations between ancestry groups, emphasizing substantial similarities in the genetic architecture across diverse populations.
- The study identified 26,049 variant-trait associations, with 3,477 being significant only when individuals from non-European populations were included, showcasing the importance of genetic diversity in population-wide genetic studies.
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Genetics, Allergy & Clinical Immunology, Cardiology, Oncology