- A distinct signaling pathway called TNF-α drives the transformation of normal epithelial cells into aggressive tumor cells in key phases of tumorigenesis.
- The accumulation of mutations in cancer genes leads to clonal expansion of cells, resulting in uncontrolled cell division and the development of cancer.
- The TNF-α signaling program acts as a main driver for the transformation of normal cells to malignant cancer cells, contributing to tumor initiation and invasive properties of epidermal stem cells.
- The research team identified a distinct TNF-α program that is crucial in inflammation and cellular communication, playing a role in the transformation of normal cells into cancer cells.
- Understanding the TNF-α signaling in tumor evolution may lead to new strategies for early detection, prevention, and treatment of epithelial cancers, offering a potential therapeutic avenue for patients and providing a biomarker for assessing prognosis.
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Oncology, Pathology&LabMedicine