Researchers uncover how protein OTX2 drives aggressive childhood brain cancer in surprising new ways, shedding light on potential therapeutic strategies.
- Protein OTX2 plays a significant role in driving the progression of medulloblastoma, the most common aggressive childhood brain cancer.
- Researchers found that OTX2 interacts with splicing factors, affecting alternative splicing and leading to the development of medulloblastoma.
- Targeting OTX2 or its effects could have therapeutic relevance in treating medulloblastoma.
- Disturbing the splicing of the gene PPHLN1, fueled by OTX2, can reduce tumor growth, offering new treatment possibilities.
- The study highlights the importance of collaboration and unbiased multi-level studies in advancing knowledge about how OTX2 contributes to medulloblastoma development.
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Oncology, Neurology