- Depression is associated with interest-activity symptoms such as low mood, fatigue, cognitive impairments, and anhedonia, hindering work and social interactions.
- Traditional treatments like serotonin reuptake inhibitors have low success rates due to the complexity of depression.
- Physical activity, especially aerobic exercise, improves dopamine transmission, reduces oxidative stress, and cognitive impairments in depression patients.
- Motivational dysfunction in depression is linked to impaired reward processing, cognitive control, and inflammation.
- Aerobic exercise has been found to significantly improve depressive symptoms by boosting dopamine transmission, lowering inflammation, and decreasing effort sensitivity.
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Psychiatry & Mental Health, Neurology, Public Health & Prevention
