University of Arizona researchers have discovered a novel way to enhance the effectiveness of opioids while reducing side effects.
- Researchers at the University of Arizona Health Sciences have discovered a new method to enhance the pain-relieving properties of opioids while reducing unwanted side effects by inhibiting a specific isoform of Heat shock protein 90 in the spinal cord.
- The study suggests that selective Hsp90 inhibitors could be used in combination with opioid therapy to decrease the amount of opioids needed for pain relief and lower the risk of side effects such as addiction and respiratory depression.
- By targeting individual isoforms of Hsp90, researchers were able to amplify the pain-relieving effects of morphine in mouse models, while reducing tolerance and reversing established tolerance.
- The goal is to develop a combination therapy of opioids with isoform inhibitors to improve pain relief and minimize side effects, offering better treatment options for individuals with chronic pain.
- Researchers are now working on optimizing selective Hsp90 inhibitors to create a stable drug that can be taken orally, with the hope of revolutionizing pain management and addiction treatment in healthcare.
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Pharmacists, Pain Management, Neurology