Yale-led study uncovers potential target for treating autoimmune diseases through immunology research.
- Yale-led study identifies potential link between mutations in PI3Kγ and autoimmune diseases in a young girl with immune deficiencies.
- Deficiency in PI3Kγ was found to drive immune-mediated damage in the patient’s gut and lungs, leading to low antibody levels.
- Research shows that PI3Kγ plays a crucial role in allowing activated B cells to differentiate into antibody-secreting cells.
- Therapeutic blocking of PI3Kγ may help treat the overproduction of antibodies in autoimmune diseases, potentially providing a new approach for intervention.
- Further studies using PI3K inhibitors in pre-clinical autoimmunity mouse models are planned to evaluate their potential as treatment options.
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